TY - JOUR AU - Prempree, Preecha AU - Mungaomklang, Anek AU - Tangkiatkumjai, Mayuree AU - Phodha, Tuangrat AU - Kwankhao, Pakakrong AU - Chewchuapun, Kanokwan AU - Charuenporn, Chutima AU - Monta, Darika AU - Karapakdee, Thanawut PY - 2022 TI - SARS-CoV-2 Clearance from Andrographis paniculata, Boesenbergia rotunda, and Favipiravir among Mild COVID-19 Cases in Klong Prem Central Prison during Mid-2021: a Retrospective Study JF - OSIR Journal; Volume 15 Issue 4 ( 2022 ): Outbreak, Surveillance, Investigation & Response (OSIR) Journal KW - N2 - This study aims to assess the effectiveness of two herbal medicines, Andrographis paniculata (Burm.f.) Nees capsule (AP) and Boesenbergia rotunda (Linn.) Mansf. extract capsule (BR), on the rate of SARS-CoV-2 virus clearance among inmates of Klong Prem Central Prison, Bangkok. Cases with mild COVID-19 were allocated into four groups: four capsules of AP thrice daily (n=30), one capsule of BR once daily (n=30), a combination of AP and BR (AP-BR) (n=30), or favipiravir (n=30) for five days. The primary outcome was time until undetected SARS-CoV-2 infection after starting treatment. The median period of SARS-CoV-2 clearance was shorter in the AP and AP-BR groups (9 days) compared to the BR (11 days) and favipiravir (13 days) groups. No one developed pneumonia; however, one participant in the AP group developed hyperkalemia. Our results suggest that A. paniculata with or without B. rotunda may be used as an alternative treatment for mild COVID-19 when access to favipiravir is limited. Further clinical trials are needed to determine their efficacy and safety. Keywords:  Andrographis paniculat a, Boesenbergia rotunda , favipiravir, mild COVID-19 UR - https://osirjournal.net/index.php/osir/article/view?path=